New Ways to Make and Analyze Sugars and Sugar-Containing Materials
Our group is finding new ways to make and analyze sugars and sugar-containing materials to dissect their important roles especially in defenses against disease, in plants, animals, and humans. One major long-term goal is to rationally design biomaterials and therapeutic interventions such as vaccines based on a deeper knowledge of these carbohydrate interactions. Most recently, we have created the first automated solution-phase method to readily synthesize oligosaccharides using methodologies that we are applying to other biologically active molecules. This automated method circumvents key problems encountered with the solid-phase approaches that allowed commercial automated synthesis of other biopolymers like DNA and peptides.
Trevor Douglas
Earl Blough Professor of Chemistry
Chemical Biology, Inorganic, Materials
Caroline Chick Jarrold
Class of 1948 Herman B Wells Endowed Professor
Adjunct Professor, Physics
Martin F. Jarrold
Distinguished Professor and Robert & Marjorie Mann Chair
Nicola L. B. Pohl
Professor and Joan & Marvin Carmack Chair, Associate Dean of Natural and Mathematical Sciences
