Advancing Biotechnology in Academic and Commercial Ventures
At Indiana University his research group has discovered a set of incretin peptides that demonstrate unprecedented activity in animal models of diabetes and obesity. The central elements to success has been the chemistry to install within single peptides simultaneous agonism at related G-protein coupled receptors, and the counter-intuitive discovery that glucagon and GIP agonism could synergize the proven efficacy of GLP-1 in the treatment of the metabolic syndrome. Drug candidates differing in biochemical character are independently being advanced clinically by three separate pharmaceutical companies.
Trevor Douglas
Earl Blough Professor of Chemistry
Chemical Biology, Inorganic, Materials
Caroline Chick Jarrold
Class of 1948 Herman B Wells Endowed Professor
Adjunct Professor, Physics
Martin F. Jarrold
Distinguished Professor and Robert & Marjorie Mann Chair
Nicola L. B. Pohl
Professor and Joan & Marvin Carmack Chair, Associate Dean of Natural and Mathematical Sciences
