Indiana University Bloomington Indiana University Bloomington IU Bloomington

Nonlinear Infrared Spectroscopy as a Tool for the Measurement of Protein Flexibility


Newly arrived faculty member Megan Thielges is developing nonlinear infrared spectroscopy as a tool for the measurement of protein flexibility, i.e. the fast wiggling of the protein's amino acids. To generate a picture of the structural fluctuations of proteins with both high spatial and temporal resolution, the ultrafast spectroscopic methods are combined with methods of biochemistry and chemical biology for placing vibrational probe groups at specific sites throughout proteins. This approach will not only enable the testing of the contribution of motion to protein function, but also will permit characterization of many proteins that play key roles in biology that are difficult to study because of their high mobility in solution.


Veronica Siedle Associate Professor

Inorganic

Energy, Synthesis, Catalysis

James F. Jackson Professor of Chemistry

Organic

Life, Synthesis, Catalysis

Distinguished Professor
Professor and Robert & Marjorie Mann Chair

Analytical, Physical

Life, Analysis

Distinguished Professor
Linda & Jack Gill Chair in Biomolecular Science

Chemical Biology

Life, Synthesis

Provost Professor of Chemistry

Physical

Life, Analysis, Origins

Distinguished Professor and Lilly Chemistry Alumni Professor

Chemical Biology

Life

Veronica Siedle Professor of Chemistry

Inorganic

Energy, Synthesis, Catalysis

Professor
Adjunct Professor, Physics

Materials, Physical

Energy, Life

Professor
Dorothy & Edward Bair Chair

Analytical

Life, Analysis, Origins

Class of 1948 Herman B Wells Endowed Professor
Adjunct Professor, Physics

Inorganic, Materials, Physical

Energy, Catalysis

Distinguished Professor and Robert & Marjorie Mann Chair

Analytical, Materials, Physical

Analysis, Origins

Professor and Joan & Marvin Carmack Chair, Associate Dean of Natural and Mathematical Sciences

Analytical, Chemical Biology, Organic

Life, Synthesis

Associate Professor (SPEA),
Adjunct Professor (Chemistry)

Analytical, Physical

Analysis, Origins, Catalysis

James F. Jackson Associate Professor of Chemistry

Organic

Life, Synthesis, Catalysis

Adjunct Professor

Physical

Department Chair and Professor

Materials, Physical

Energy, Origins, Catalysis

Professor & Associate Vice President for Engagement

Chemical Biology, Organic

Life, Synthesis

Distinguished Professor and Harry G. Day Chair

Organic

Life, Synthesis