Nonlinear Infrared Spectroscopy as a Tool for the Measurement of Protein Flexibility
Newly arrived faculty member Megan Thielges is developing nonlinear infrared spectroscopy as a tool for the measurement of protein flexibility, i.e. the fast wiggling of the protein's amino acids. To generate a picture of the structural fluctuations of proteins with both high spatial and temporal resolution, the ultrafast spectroscopic methods are combined with methods of biochemistry and chemical biology for placing vibrational probe groups at specific sites throughout proteins. This approach will not only enable the testing of the contribution of motion to protein function, but also will permit characterization of many proteins that play key roles in biology that are difficult to study because of their high mobility in solution.
Distinguished Professor
Robert & Marjorie Mann Chair
Distinguished Professor
Linda & Jack Gill Chair in Biomolecular Science
James F. Jackson Professor of Chemistry
Class of 1948 Herman B Wells Endowed Professor
Adjunct Professor, Physics
Associate Dean of Natural and Mathematical Sciences and Research
Associate Professor (O'Neill School of Public and Environmental Affairs),
Adjunct Professor (Chemistry)
Rudy Professor (O'Neill School of Public and Environmental Affairs)
Adjunct Professor (Chemistry)
Professor & Associate Vice President for Engagement
Professor, Department of Molecular and Cellular Biochemistry
Adjunct Professor