Changes in Glycosylation of Certain Blood Proteins Can be Highly Significant Attributes of Human Diseases Including Cancer
Analytical measurements of glycomic changes are rapidly becoming important in the discovery of disease biomarkers. Developing new methods for glycoprotein preconcentration and quantitative glycomic profiling through chromatography and biomolecular mass spectrometry at high sensitivity has been central to our research program. This is exemplified by our recent discovery of unusual hyperfucosylated glycan structures in the pancreatic cyst fluids of cancer patients with high metastatic potential. Their typical quantitative profile is shown above.
Distinguished Professor
Professor and Robert & Marjorie Mann Chair
Distinguished Professor
Linda & Jack Gill Chair in Biomolecular Science
James F. Jackson Professor of Chemistry
Class of 1948 Herman B Wells Endowed Professor
Adjunct Professor, Physics
Associate Dean of Natural and Mathematical Sciences
Associate Professor (SPEA),
Adjunct Professor (Chemistry)
Standiford H. Cox Professor of Chemistry
Professor & Associate Vice President for Engagement
