Advances Towards Complex Polysaccharides and Peptidoglycans Using Automated Flow Chemistry

Automated flow chemistry is gaining interest in different industries and has several advantages over batch processes, such as a decrease in reaction time, high efficiencies, large-scale product formation, and the ease of cooling and heating a reaction. Manual batch synthesis of plant-based polysaccharides and bacterial-based peptidoglycans has several challenges in terms of reproducibility and product efficacy. Similarly, automated-solid phase synthesis of such molecules has limitations associated with its complex setup, cost, and overall product yields. On the other hand, convergent automated liquid phase synthesis of these complex molecules has several advantages but unfortunately, such methods have not been reported so far. Herein, my work focuses on an automated convergent flow synthesis of plant and bacterial based-complex
molecules. This method is highly reproducible, less expensive, scalable, and product efficient. This work will open a new door for the synthesis of other plant and bacterial based highly complex molecules and their building blocks.