New Ways to Make and Analyze Sugars and Sugar-Containing Materials
Our group is finding new ways to make and analyze sugars and sugar-containing materials to dissect their important roles especially in defenses against disease, in plants, animals, and humans. One major long-term goal is to rationally design biomaterials and therapeutic interventions such as vaccines based on a deeper knowledge of these carbohydrate interactions. Most recently, we have created the first automated solution-phase method to readily synthesize oligosaccharides using methodologies that we are applying to other biologically active molecules. This automated method circumvents key problems encountered with the solid-phase approaches that allowed commercial automated synthesis of other biopolymers like DNA and peptides.