Research Divisions

Studying the Biophysical Chemistry of Infectious Disease


We are a highly collaborative, problem-oriented group that uses the tools of structural and chemical biology and biophysical chemistry to understand biological regulation at the molecular level. Current projects are focused on 1) transition metal homeostasis and resistance in microbial pathogens; 2) inorganic sulfur sensing and assimilation by the major hospital pathogen Staphylococcus aureus, and 3) RNA structure and protein-RNA interactions in SARS (severe acute respiratory syndrome)-related coronaviruses. Biomolecular NMR spectroscopy to understand the structure and dynamics of proteins and RNAs figures prominently in our research.


David P. Giedroc

Lilly Chemistry Alumni Professor

Chemical Biology