Charactering RNA and Protein Macromolecules Using Techniques Including X-ray Crystallography to Understand Molecular Interactions
The Dann lab characterizes RNA and protein macromolecules using techniques including X-ray crystallography to understand molecular interactions at the level required to development therapeutics for human disease or in vivo biosensors for small molecules. Our research revolves around small molecule sensing by both RNAs and proteins. Specifically, we are interested in human folate trafficking as it relates to targeted drug delivery for the treatment of cancer and autoinflammatory disease as well as the development of RNA-based biosensors using naturally occurring riboswitches as scaffolds. Researchers in the lab will learn computational modeling, structural and biophysical techniques in addition to biochemistry and molecular biology in both RNA and protein systems.