Research Divisions

Advancing Biotechnology in Academic and Commercial Ventures


At Indiana University his research group has discovered a set of incretin peptides that demonstrate unprecedented activity in animal models of diabetes and obesity. The central elements to success has been the chemistry to install within single peptides simultaneous agonism at related G-protein coupled receptors, and the counter-intuitive discovery that glucagon and GIP agonism could synergize the proven efficacy of GLP-1 in the treatment of the metabolic syndrome. Drug candidates differing in biochemical character are independently being advanced clinically by three separate pharmaceutical companies.


Richard DiMarchi

Distinguished Professor
Linda & Jack Gill Chair in Biomolecular Science

Chemical Biology