Chemical Biology


Redefining the interface between chemistry, biology and human health

Chemical Biology is home for our interdisciplinary graduate training program in Quantitative and Chemical Biology (QCB) and attracts students interested in exploring problems at the interface of chemistry, biology, and human health.  A highly collaborative research environment that integrates synthesis, structural biology, biophysical chemistry, proteomics, drug discovery and state-of-the-art instrumentation provides students an unparalleled opportunity to design a unique course of study in preparation for careers in academic science and biotechnology.

Faculty

Jonathan Trinidad Hongwei Wu Vasily Gelfanov Binbin Kou Pengyun Li Bin Yang Charles Dann III Richard DiMarchi Trevor Douglas David P. Giedroc Milos Novotny Martha Oakley Peter Ortoleva Nicola L. B. Pohl Jonathan Schlebach Megan Thielges Michael VanNieuwenhze Theodore Widlanski Yan Yu Adam Zlotnick

Research

Advancing Biotechnology in Academic and Commercial Ventures

Advancing Biotechnology in Academic and Commercial Ventures

At Indiana University his research group has discovered a set of incretin peptides that demonstrate unprecedented activity in animal models of diabetes and obesity. The central elements to success has been the chemistry to install within single peptides...
Charactering RNA and Protein Macromolecules Using Techniques Including X-ray Crystallography to Understand Molecular Interactions

Charactering RNA and Protein Macromolecules Using Techniques Including X-ray Crystallography to Understand Molecular Interactions

The Dann lab characterizes RNA and protein macromolecules using techniques including X-ray crystallography to understand molecular interactions at the level required to development therapeutics for human disease or in vivo biosensors for small molecules....
Developing New Technologies to Explore Bacterial Pathogenesis

Developing New Technologies to Explore Bacterial Pathogenesis

Former Professor Erin Carlson’s research program focused on the development and application of new technologies to explore the mechanisms of bacterial pathogenesis and identify potential therapeutic agents. To accomplish these goals, we work at the i...
Studying the Biophysical Chemistry of Infectious Disease

Studying the Biophysical Chemistry of Infectious Disease

We are a highly collaborative, problem-oriented group that uses the tools of structural and chemical biology and biophysical chemistry to understand biological regulation at the molecular level. Current projects are focused on 1) transition metal homeostasis...
Studying the Structure and Function of Bacterial Proteins

Studying the Structure and Function of Bacterial Proteins

The Oakley lab studies the structure and function of bacterial proteins that are important for the appropriate distribution of chromosomes into daughter cells. Their work takes advantage of structural understanding of the E. coli condensin, MukB,...