Changes in Glycosylation of Certain Blood Proteins Can be Highly Significant Attributes of Human Diseases Including Cancer
Analytical measurements of glycomic changes are rapidly becoming important in the discovery of disease biomarkers. Developing new methods for glycoprotein preconcentration and quantitative glycomic profiling through chromatography and biomolecular mass spectrometry at high sensitivity has been central to our research program. This is exemplified by our recent discovery of unusual hyperfucosylated glycan structures in the pancreatic cyst fluids of cancer patients with high metastatic potential. Their typical quantitative profile is shown above.