Analytical


Instrumentation and methods for analysis on new frontiers

Fundamental and practical measurement of chemicals, biomolecules, and materials is critical to the advancement of every aspect of modern science. Analytical Chemistry is the science devoted to the development of new instrumentation and methods to enable such measurements in all shapes and forms. Extraordinary facilities for instrumentation and electronics conception, design, testing, and application, coupled with rigorous student training, have created a vibrant, dynamic, top-ranked program in Analytical Chemistry at Indiana University. Traditional analytical approaches – mass spectrometry, optical spectroscopy, separations, and electrochemistry – are augmented by interdisciplinary efforts in chemical biology and materials chemistry. Our mission is to conceive, define, and develop future analytical tools and methods and to train the next generation of leaders in the field.

Faculty

Xinfeng (Frank) Gao Jonathan Karty Jonathan Trinidad Helena Soini Lane A. Baker David Clemmer Gary Hieftje Ronald A. Hites Stephen C. Jacobson Martin F. Jarrold Milos Novotny Dennis Peters Nicola L. B. Pohl Jonathan Raff James Reilly Megan Thielges Yan Yu

Research

Changes in Glycosylation of Certain Blood Proteins Can be Highly Significant Attributes of Human Diseases Including Cancer

Changes in Glycosylation of Certain Blood Proteins Can be Highly Significant Attributes of Human Diseases Including Cancer

Analytical measurements of glycomic changes are rapidly becoming important in the discovery of disease biomarkers. Developing new methods for glycoprotein preconcentration and quantitative glycomic profiling through chromatography and biomolecular mass...
Developing Tools and Models for Chemical Measurement

Developing Tools and Models for Chemical Measurement

Chemically-selective nanopipettes, methods to measure ion concentrations with scanning ion conductance microscopy (SICM), and methods to control ion transport using magnetic fields are a few examples. We are focused on questions related to epithelial...
Exploiting the Remarkable Properties of Laser Light in Various Experiments

Exploiting the Remarkable Properties of Laser Light in Various Experiments

Our research group exploits the remarkable properties of laser light in various experiments in bioanalytical chemistry and high resolution mass spectrometry. We are interested in both the development of new techniques and in their application to solving...
Exploring the Use of Silver Cathodes which Possess Exceptional Catalytic Activity

Exploring the Use of Silver Cathodes which Possess Exceptional Catalytic Activity

As part of our research in electrochemistry, we are exploring the use of silver cathodes which possess exceptional catalytic activity toward the reduction of halogenated organic compounds. Direct reduction of 6-iodo-1-phenyl-1-hexyne at a silver cathode...
Nanofluidic Devices are Able to Sense, Separate, and Sort Individual Molecules

Nanofluidic Devices are Able to Sense, Separate, and Sort Individual Molecules

Nanofluidic devices are able to sense, separate, and sort individual molecules with unprecedented precision because of the unique transport properties these nanoscale conduits exhibit. With nanofabrication techniques, we are able to create fluidic circuits...
Nonlinear Infrared Spectroscopy as a Tool for the Measurement of Protein Flexibility

Nonlinear Infrared Spectroscopy as a Tool for the Measurement of Protein Flexibility

Newly arrived faculty member Megan Thielges is developing nonlinear infrared spectroscopy as a tool for the measurement of protein flexibility, i.e. the fast wiggling of the protein's amino acids. To generate a picture of the structural fluctuations...
Studying Novel Kinds of Glow Discharges

Studying Novel Kinds of Glow Discharges

Such discharges are sometimes operated at reduced pressure and sometimes at atmospheric pressure. The one shown in this image is in the open atmosphere and strikes directly onto the surface of a solution sample. Elements in that sample are volatilized,...
Studying Protein Structures in the Gas Phase

Studying Protein Structures in the Gas Phase

Although the "native" solution structures of many proteins are known, little is known about how denatured forms fold into the native state. This is because isolating and determining structures for a large number of solution-phase intermediates is difficult....