QCB logo and title
Co-Directors:

David Giedroc and Nikki Pohl

Steering Committee:

Claire Walczak, Bogdan Dragnea, David Giedroc (chair), Nikki Pohl, Sid Shaw, Adam Zlotnick


Curriculum Committee:

Stephen Jacobson, Suchetana Mukhopadhyay, Martha Oakley (chair), Sima Setayeshgar

Recruitment Committee:

Steve Bell, Bogdan Dragnea (chair), Paul Sokol, Malcolm Winkler


Administrative Support:

Kristina McReynolds (pre-award) Erin Edwards (post-award)


news

Septermber 2014: August 2014 meeting minutes of the QCB TP preceptor meeting are available here.

August 29, 2014: Our annual meeting of current QCB TP preceptors will take place 3:00-4:00 pm, Chemistry C127.

June 2014: The 2014-15 QCB graduate fellowships were selected out of 12 applications from 12 different trainers.  Congratulations to Britta Rued (Winkler Lab), Rachel Horness (Thielges Lab) who received two-year fellowships and Lucy Sanchez (Yu Lab) and Drew Elliot (Shaw Lab) who received one-year fellowships effective July 1, 2014!

April 2014: Our institutional training grant application requesting five years of support from NIGMS for the QCB TP has been funded (2014-2019)!!  Please cite fellowship support from the NIH (T32 GM109825) or Indiana University whenever a trainee supported by the QCB TP is a co-author on a publication.

April 2014: Call for one to two year QCB fellowship applications for support beginning July 1, 2014 is now open. Second and third-year students are encouraged to apply. Click here for the solicitation letter and outline of the application. Applications are due May 12, 2014.

December 2013: The 2014 QCB graduate fellowships were selected out of 11 applications from 10 different trainers. Congratulations to Edward Basom (Thielges Lab), Kendall Mayer (Giedroc Lab) and Elizabeth Yuill (Baker Lab) who received the one-year fellowship effective January 1, 2014!

September 2013: Call for one-year QCB fellowship applications for support from January 1, 2014-December 31, 2014 is now open. Second-year students are particularly encouraged to apply. Click here for the solicitation letter and outline of the application. Applications are due December 1, 2013.

July 2013: July 2013: Meeting minutes of the QCB TP preceptor meeting are available here.

May 2013: Our institutional training grant application requesting five years of support from NIGMS for the QCB TP has been submitted!! Please click here to review the proposal.

December 2012: David Keifer (M. Jarrold Lab), Andy Johnson (Carlson Lab) and Anna Weber (Baker Lab) have been selected to receive the QCB graduate fellowship.These fellowships are effective January 1, 2013 for a one-year period with a second year of support possible.  Congratulations David, Andy and Anna!

August 2012: The QCB TP welcomes the addition of four new trainers.  They are Nikki Pohl, Carmack Chair in Bioorganic Chemistry, and three Assistant Professors, Jared Cochran (Biochemistry), Megan Thielges (Chemistry) and Yan Yu (Chemistry).  Nikki Pohl joins David Giedroc as a co-Director of the Program.

QCB TP at IU

Major innovations in biomedical science will become increasingly dependent on scientists trained to understand the chemical and physical logic of biological systems in quantitative terms. We seek to use the training program to leverage our strengths in analytical chemistry and instrumentation development in the creation of new didactic courses and research opportunities focused on interdisciplinary graduate training in the biological sciences.

Mission

The central goal of our NIH-funded Quantitative and Chemical Biology Training Program (QCB TP) is to build and foster an interdisciplinary graduate training environment which promotes a “convergence of fields” that transcends departmental boundaries.  In short, we seek to train a diverse cohort of students from the chemical, physical and life sciences to address problems central to understanding human health and disease.

Instrumentation

QCB TP preceptors and students enjoy access to a remarkable collection of sophisticated instrumentation including a state-of-the-art nanofabrication and characterization facility, a 300 keV cryo-transmission electron microscope, 800 and 600 MHz NMR spectrometers with cryoprobe systems and a modern x-ray crystallography core equipped with a sample preparation robot. In addition, the Light Microscopy and Imaging Center houses a super-resolution DeltaVision|OMX light microscope, one of the few sited in the country.

This instrumentation coupled with myriad high resolution mass spectrometers used for proteomics, glycomics and metabolomics housed in the Laboratory for Biological Mass Spectrometry (LBMS) as part of a Waters Corporation Center for Innovation, make the Bloomington campus an outstanding venue in which to obtain interdisciplinary graduate training in QCB.

QCB TP Fellowships

QCB Graduate Training Fellowships are competitively awarded to second- and third-year students working on projects at the interface and are supported by a combination of funding provided by the NIH grant, the College of Arts and Sciences and the University Graduate School.  Current and previous QCB TP trainees work in the Baker, Dragnea, Giedroc, Jarrold, Jacobson, Shaw, Thielges, Winkler and Yu laboratories.

The next fellowship competition will take place in May 2015.  Students entering the second and third year as of July 1, 2015 are encouraged to apply for a two- or one-year fellowship period, respectively.  Click here for information required to apply for a QCB TP fellowship.

2014 Watanabe Symposium in Chemical Biology

Indiana University and QCB TP annually host a research symposium in honor of August "Gus" Watanabe, a renowned physician, researcher and professor who led research and development at Eli Lilly and Company for nearly a decade, and who was a pioneer in the study of the cellular mechanics of the heart. Watanabe assumed the role as President of Lilly Research Laboratories in 1994 and under his guidance, Lilly launched 11 important new pharmaceutical products.

This year's event will occur on Saturday, October 11, 2014 in C122, Chemistry Building from 8:30 am - 3:30 pm and features oral presentations by four internationally recognized invited speakers as well as, several QCB TP preceptors. A poster session to showcase research activities in QCB TP laboratories is also planned.

Invited speakers this year include Catherine L. Drennan (Massachusetts Institute of Technology), Xiaowei Zhuang (Harvard University), Michael A. Weiss (Case Western Reserve University) and Philip S. Low (Purdue University).

Click here for information on the 2013, 2012, 2011 and 2010 events.

Curricular requirements of the QCB TP

Text Box:  The QCB TP is designed to attract students with undergraduate degrees in chemistry, biology, biochemistry, biophysics or physics who seek to develop and utilize leading-edge technologies to explore biological problems important in human health and disease.  The overriding principle that governs development of the curriculum is that it is value-added on a traditional core disciplinary program of study.  We establish the program in this way because the program itself is not degree-granting.  Prospective trainees are admitted to Graduate School in one of five departments or programs and earn their Ph.D. degrees in that department or program, i.e., Chemistry, Physics, Biochemistry, Biology or Medical Science.

The proposed QCB TP is schematized in the figure right and is managed by the Curriculum Committee.  It emphasizes the centrality of QCB TP requirements on what is otherwise a standard, distinct disciplinary focus.  The two core didactic courses are CHEM C680, Introduction to Quantitative Biology and Measurement and CHEM C681 (formerly C687), Introduction to Chemical Biology I. These courses are designed to arm the student with a fundamental "language" or “tool-box” of chemical and physical biology.  All QCB TP students will also register for CHEM C689, QCB Journal Club in the second and third years, with the remaining curricular requirements (3 cr) satisfied by any number of a large list of electives outside of disciplinary courses.  The Topics-based e-modules are currently under development and will debut in Fall 2014.  Completion of C680/C681 and 3 cr of approved QCB TP elective courses (6 cr total) also satisfy the curricular requirements for an approved graduate minor in Quantitative Biology (QB).

Extracurricular activities associated with the QCB training program include the Watanabe Symposium in Chemical Biology, Monthly QCB Evenings, and QCB Seminar Series.  We will debut the QCB Seminar series in Spring 2015 (and planned annually for the Spring semester) and Monthly QCB Evenings in Fall 2014.  Stay tuned!

New students:

Interested?  Submit your application for admission to a degree-granting program in Biology, Biochemistry, Chemistry, Medical Sciences or Physics (biophysics), and click the QCB interest box on the formal application form.  Alternately, contact any member of the Steering Committee or the Recruitment Committee for additional information.  We’ll find you!