Research & Analytical Centers
- Center for Cell and Virus Theory
- Linda and Jack Gill Center for Biomolecular Science
- Indiana Instrumentation Institute
- Laboratory for Biological Mass Spectrometry
- Electron Microscopy Center
Center for Cell and Virus Theory
The Center for Cell and Virus Theory is a research institute, with the main objective of developing mathematical and computational models of the physical and chemical processes for underlying cell and virus behavior. The CCVT addresses the challenge of understanding the workings of life on multi-, single- and sub-cellular scales. The interdisciplinary approach of the CCVT integrates methods from statistical mechanics, quantum chemistry, chemical kinetics, cell physiology, virology, biochemistry and computational sciences. Information theory is used to integrate models with data to produce a revolutionary automated model development, calibration and risk assessment approach.
Applications of our software include microarray, NMR and proteomic data analysis. Specific technologies also include drug and vaccine discovery, nanoparticle drug delivery, system design, environmental remediation and bio-reactor optimization. Disease groups under active research include those induced by viral and bacterial pathogens, cancer and diabetes.
Linda and Jack Gill Center for Biomolecular Science
The Linda and Jack Gill Center for Biomolecular Science (GCBS) was established to advance the understanding of complex biological processes and to train next generation scientists in state-of-the-art biomolecular measurements, especially in the field of neuroscience. Collaborations include Indiana University's world-class Departments of Biology, Chemistry, Physics, Psychological and Brain Science , Neuroscience, and the School of Medicine.
Specific GCBS Goals:
- Bring together multidisciplinary teams of world-class faculty interested in state-of-the-art biomolecular measurements to understand complex biological processes, especially neuroscience
- Provide training to graduate students from a range of disciplines in the use and development of measurement techniques and instrumentation
- Provide undergraduate students an opportunity to be involved in cutting-edge research projects
- Encourage interaction with industry in order to identify important problems and to commercialize advances
- Widely disseminate advances in complex biomolecular measurement techniques and instrumentation
Indiana Instrumentation Institute
The long-standing strengths in chemical instrumentation and analytical chemistry at both Indiana University and Purdue University led to the founding of the Indiana Instrumentation Institute (III). III was established to formalize and strengthen existing relationships between Purdue University, Indiana University, and State industry in the area of scientific instrumentation. The focus is on development of new instrumentation, improvement in instrumentation infrastructure, and partnerships with industries involved in chemical measurements.
Key objectives of the institute consist of: accelerating the transfer of advanced instrumentation and technology from university laboratories into marketable products; diversifying Indiana's economy by focusing investment in biomedical research and biotechnology, information technology, and other high technology industry clusters requiring high skill, high wage employees; assisting graduate students and others in founding start-ups companies based on research work done at Purdue and IU; developing programs of research in mass spectrometry and optical imaging; creating specialized facilities and infrastructures needed for development of new types of instruments; and encouraging an environment of innovation and cooperation among universities and businesses to promote research activity
Laboratory for Biological Mass Spectrometry
The Laboratory for Biological Mass Spectrometry is located in Simon Hall 115 as well as Chemistry 235. It houses equipment for mass spectrometric characterization of proteins, lipids, carbohydrates and metabolites. Major instrumentation include a Synapt G2 HDMS, an LTQ Orbitrap, an LTQ Velos Pro and a QTRAP 4000. The Laboratory performs a variety of analyses. It specializes in the identification and characterization of protein-interactions, protein post-translational modifications, and quantitative comparisons of complex samples.
Electron Microscopy Center
The Electron Microscopy Center has instrumentation in both Myers Hall (room 040) and Simon Hall (room 032), and a staff with over 70 years combined experience in various aspects of biological and materials science electron microscopy. The facility houses two transmission electron microscopes (TEM's) and a scanning electron microscope (SEM).The JEOL 1010 (100 kV) TEM is our workhorse TEM and is useful for samples that require moderate magnifications (below 100,000x) and simple imaging or electron diffraction studies. The JEOL 3200FS (300 kV) TEM can operate at higher magnifications and with higher resolution, and is equiped with various additional detectors for analytical electron microscopy. The 3200FS also has specimen holders that allow it to perfrom cryo-imaging and tomography of both room temperature and cryo samples. The JEOL 5800LV SEM is a moderate resolution SEM that can operate under both high and low vacuum conditions. It also has a very large specimen chamber that can hold up to 7 conventional SEM samples, or a single object as large as 20 cm (8 inches) in diameter.
In addition to the imaging instrumentation, the EMC also houses equipment for various types of sample preparation. This includes two plunge freezers for cryoTEM grid preparation, a new high pressure freezer and freeze substitution device for preparing various types of cells and tissue, a critical point dryer and sputter coater for SEM samples and several ultramicrotomes. In addition to these resources, the EMC also handles the archiving of digital images collected with our instruments and supports a variety of computational resources for image processing and analysis.