Instrumentation

Waters Synapt G2 HDMS

This is a high mass accuracy mass spectrometer equipped with an ion mobility cell. In addition to standard collision induced dissociation (CID), this instrument can also conduct fragmentation via electron transfer dissociation (ETD). Principle uses include metabolite profiling and identification, analysis of intact proteins, and identification of peptides and post-translationally modified peptides.

Thermo Scientific LTQ Orbitrap XL

This mass spectrometer combines an LTQ analyzer with an Orbitrap high resolution mass analyzer. It is used for the characterization of intact proteins as well as the identification of peptides and metabolites.

Thermo Scientific LTQ Velos Pro

This mass spectrometer is the newest generation ion trap. While relatively low resolution, it has extremely fast scan speeds and low sensitivity. These characteristics make it ideal for characterization of protein digests ranging in complexity from in-gel digestions to whole cell lysates.

AB SCIEX 4000 QTRAP

This is a hybrid triple quadrupole/linear ion trap mass spectrometer. It is used primarily to quantify previously characterized small molecules and peptides in a highly reproducible fashion.

Bruker Daltronics micrO TOF

The micrO Tof is and ESI time of flight mass spectrometer used for accurate mass determination and method development.

Bruker Daltronics HCT Ultra

The HCT Ultra is an ESI ion trap mass spectrometer. It can fragment ions by either CAD or ETD and is equipped with a UV detector to allow for combined UV-MS detection.